Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar
نویسندگان
چکیده
Integrins are the glue that maintain cell-to-cell adhesion and are found in nearly all cell types and function as heterodimeric cell surface receptors. Although not regarded as active signaling receptors in the basal state, integrins transduce signals that regulate fibrosis, angiogenesis, cellular migration, and other wound-healing processes during pathologic conditions.1,2 In this issue of Cellular and Molecular Gastroenterology and Hepatology, Ulmasov et al3 report that a synthetic peptide (CWHM-12) containing a conserved Arg-GlyAsp (RGD) integrin-recognition domain ameliorated cerulein-induced pancreatic fibrosis and pancreatic stellate cell (PSC) activation by inhibiting transforming growth factor (TGF)β activation.
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